Zero is the final boss of Hard mode dungeons, on the 20th floor. Armed with the
Control fruit, he locks the room in his Control Domain and deals extreme damage: he's the last obstacle before dungeon rewards.
How to get it
No summoning: you face him on the 20th floor of a Hard mode dungeon. It's typically the final battle before claiming your rewards (except on Challenge difficulty).
How to defeat it
Upon arrival, he opens the Control Domain which engulfs almost the entire room leaving only the corners; he is vulnerable one second after his animation, and the domain remains active indefinitely (he will not cast this move again). His damage is extreme: play at range and take advantage of the long windows where he stays still preparing Slice N' Dice or Gamma Blade to punish him. Gamma Blade can be dodged with
Instinct, but be careful of his combined version which ends up exploding and breaking it. After reappearing once, around 50% HP, he spawns floating cubes in the room at regular intervals: destroy them as fast as possible with destructible physical attacks. He also teleports randomly around the room (Transmutation), so stay on your guard.
Our take
The final boss of Hard mode: monstrous damage but generous punish windows - distance and cube management are key.